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Noticias de Salud.

Muertos por √©bola superan los 1200 en el oeste de √Āfrica: OMS 20 Aug 2014


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Los casos por el brote de √©bola en el oeste de √Āfrica este a√Īo han subido a 2240, incluyendo 1229 muertes, dijo el martes la Organizaci√≥n Mundial de la Salud (OMS), reportando las cifras de cuatro pa√≠ses, entre ellos Nigeria.

omsLa OMS dijo que está trabajando conjuntamente con el Programa Mundial de Alimentos (PMA) de Naciones Unidas para asegurar el envío de comida a un millón de personas que viven en zonas de cuarentena en Guinea, Liberia y Sierra Leona.

“Se han llevado alimentos a los pacientes hospitalizados y a las personas en cuarentena que no pueden dejar sus casas para comprar comida. Proporcionar el suministro regular de alimentos es un medio potente de limitar movimientos innecesarios”, dijo la OMS en un comunicado.

El PMA va a reforzar los envíos de urgencia a las zonas en cuarentena, entre las que hay varias ciudades muy afectadas, como Gueckedou en Guinea, Kenema y Kailahun en Sierra Leona y Foya en Liberia.

Aunque Nigeria, el pa√≠s m√°s poblado de √Āfrica y el primer productor de petr√≥leo del continente, parece estar conteniendo el brote, Liberia y Sierra Leona est√°n teniendo problemas para frenar la expansi√≥n del virus mortal entre sus habitantes.

El viernes, estos dos peque√Īos pa√≠ses del oeste de √Āfrica y una ONG m√©dica criticaron a la OMS por la lentitud de su respuesta, y dijeron que hace falta una mayor intervenci√≥n para las v√≠ctimas amenazadas por el hambre y la enfermedad.
agosto 19/2014 (Reuters) -

Tomado del bolet√≠n de selecci√≥n tem√°tica de Prensa Latina: Copyright 2013 ‚ÄúAgencia Informativa Latinoamericana Prensa Latina S.A.‚ÄĚ

Descubren una pieza clave en la supervivencia de las células frente al cáncer 20 Aug 2014


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La Ligasa 3 activa permite a las células eludir la muerte y sobrevivir así a los defectos cromosómicos de la división celular repetida relacionados con la aparición del cáncer.

Ligasa 3Investigadores de la Universidad de Cardiff (Reino Unido) y de la Universidad de Minnesota (EEUU) han identificado un gen específico que necesitan las células humanas para sobrevivir a los defectos cromosómicos. El estudio, publicado en Cell Reports (doi: 10.1016/j.celrep.2014.07.007), identifica un componente esencial que permite a las células viejas eludir la muerte.

“Hemos encontrado un gen que parece ser crucial en los procesos evolutivos que pueden producir c√°ncer”, afirma Duncan Baird, de la Universidad de Cardiff.

Utilizando una sofisticada técnica de genética dirigida para desactivar genes particulares en células humanas y luego estudiar el impacto en la fusión telomérica, los investigadores encontraron que las células escapaban de la muerte sólo cuando el gen Ligasa 3 estaba activo pero no cuando su acción estaba bloqueada.

“La disfunci√≥n telom√©rica ha sido identificada en muchos c√°nceres humanos y los tel√≥meros cortos pueden predecir el resultado de los pacientes que los padecen”, explica Baird. “El hecho de que la Ligasa 3 sea necesaria para este proceso es realmente importante”.

Esta investigación fue posible gracias a un encuentro entre Duncan Baird, de la Universidad de Cardiff, y Eric Hendrickson, de la Universidad de Minnesota en una conferencia internacional.

Actualmente existen varios estudios en marcha. En particular, la dependencia en la Ligasa 3 parece ser, a su vez, dependiente de la actividad de otro gen reparador de ADN, p53. “Ahora nos corresponde descubrir c√≥mo interact√ļan estos dos genes y as√≠ ver si podemos usar esa informaci√≥n para desarrollar modalidades de tratamiento sin√©rgico”, concluye Hendrickson.
agosto 8/2014 (Diario Médico)

Jones RE, Oh S, Grimstead JW, Zimbric J, Roger L, Heppel NH.Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent.Cell Rep. 2014Ago 5.

Un nuevo sistema obtiene las im√°genes de rayos X en cinco segundos 20 Aug 2014


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Científicos de la Sociedad de Radiología de México han creado un sistema digital de rayos-X que reduce el tiempo para obtener los resultados de la prueba.

imagen-procedimiento-rayos-x_4La Sociedad de Radiología de México ha creado un sistema que disminuye el tiempo de envío de los resultados en las pruebas con rayos-X a cinco segundos y que consiste en cambiar la placa tradicional por un sólido detector. Con el método antiguo se tardaba alrededor de 6 minutos.

Este procedimiento se llama ARIX RAD y obtiene imágenes a través de rayos-X que ayudan en el diagnóstico de varias enfermedades como las fracturas de huesos, tumores o cálculos renales.

Este nuevo m√©todo consiste en reemplazar la pel√≠cula radiogr√°fica por un detector de radiaci√≥n que env√≠a se√Īales el√©ctricas proporcionales a los niveles de radiaci√≥n recibidos. Este detector tiene un dispositivo compuesto por yoduro de cesio que convierte los rayos-X en luz, la cual vuelve a convertirse en se√Īales digitales a trav√©s de una capa de fotodiodos de silicio que se procesan para conseguir una imagen.

Mejor calidad asistencial
El control y la gestión virtuales facilitan la distribución por Internet, permitiendo procesos como la teleradiología y el diagnóstico remoto. El sistema tiene una interfaz que permite seleccionar fácilmente la técnica radiográfica utilizada y por lo tanto la cantidad de miliamperios, kilovoltios, así como el tiempo requerido para realizar una placa de rayos X en función de la zona anatómica, la proyección y el peso del paciente.

Este novedoso procedimiento tiene un coste bajo, la calidad de la imagen es óptima, no es distorsionada, y los pacientes pueden ser atendidos en menos tiempo.
agosto 8/2014 (Diario Médico)

Hallan una proteína que protege el páncreas de la diabetes 20 Aug 2014


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La prote√≠na Ciclina D3 preservar√≠a a las c√©lulas beta del p√°ncreas de la diabetes de tipo 1, seg√ļn investigadores catalanes.

P√°ncreasEquipo de investigaci√≥n que ha realizado el estudio (Instituto de B√ļsqueda Biom√©dica)

Un equipo de científicos catalanes ha descubierto una proteína, la Ciclina D3, que protege a las células beta del páncreas del ataque el sistema inmunitario en la diabetes de tipo 1. Este hallazgo puede ser una vía para identificar nuevas dianas farmacológicas y alternativas terapéuticas para estos pacientes.

Esta clase de diabetes se produce por la muerte de las células beta del páncreas responsables de la elaboración de insulina. Esta células se destruyen a causa del sistema inmunitario del paciente que irrumpe en el páncreas y las elimina. Como consecuencia de esto, se produce una falta de insulina, provocando la insuficiencia de los pacientes a la hora de reaccionar ante la aparición de glucosa en la sangre.

Nueva función de protección
Esta réplica del sistema de defensa tiene como consecuencia un efecto desconocido hasta ahora, que las células beta fabrican menos proteína Ciclina D3. A través de esta vía se ha encontrado una nueva función de protección a la Ciclina D3 frente a la autoinmunidad. Además, se ha verificado que esta función la lleva a cabo sin activar una de las funciones más conocidas de esta ciclina, el desarrollo de células.

En el estudio, publicado en PNAS (doi:10.1073/pnas.1323236111 ), ha participado el Instituto de investigaciones Biom√©dicas Augusto Pi y Sunyer (Idibaps), el Instituto de B√ļsqueda Biom√©dica de L√©rida (IRBL√©rida), el Instituto de Bioingenier√≠a de la Universidad Miguel Hern√°ndez y las universidades de Barcelona y L√©rida.
agosto 8/2014 (Diario Médico)

Noem√≠ Alejandra Saavedra-√Āvila,Upasana Sengupta,Bego√Īa S√°nchez,Ester Sala,Laura Haba,Conchi Mora.Cyclin D3 promotes pancreatic {beta}-cell fitness and viability in a cell cycle-independent manner and is targeted in autoimmune diabetes PNAS. Agot 4, 2014

Mutaci√≥n en gen esencial para la regulaci√≥n celular provoca c√°ncer renal en ni√Īos 20 Aug 2014


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Las mutaciones en CTR9, encargado de la activación y desactivación de los genes, pueden provocar tumor de Wilms.

Tumor renalSeg√ļn un estudio publicado en Nature Communications (doi:10.1038/ncomms5398 ), un equipo de investigadores de The Institute of Cancer Research (Reino Unido) ha encontrado que las mutaciones en un gen que ayuda a regular la activaci√≥n de los genes en las c√©lulas provocan casos raros de tumor de Wilms, el c√°ncer renal m√°s com√ļn en ni√Īos.

Los investigadores estudiaron los genes de 35 familias con m√°s de un caso de tumor de Wilms. En seis ni√Īos de tres familias distintas encontraron mutaciones en CTR9 que hicieron que el gen dejara de funcionar correctamente. No se presentaron mutaciones parecidas en 1000 individuos sin tumor de Wilms.

CTR9 es parte de un complejo multiproteico, conocido como PAF1, que regula cuándo los genes se activan o desactivan. El complejo PAF1 tiene diversos papeles en el control de los procesos celulares y en el desarrollo de los órganos del embrión. Las mutaciones de otro gen en el complejo, CDC73, también provocan cáncer.

“Esta investigaci√≥n subraya que el mal funcionamiento del complejo PAF1 puede provocar c√°ncer. Esperamos que nuestros descubrimientos estimulen nuevas investigaciones sobre por qu√© y c√≥mo ocurre esto y conduzcan a mejores tratamientos para el c√°ncer”, ha dicho Nazneen Rahman, de The Institute of Cancer Reseacrh.

“Ahora podemos realizar un sencillo an√°lisis de sangre para ver qu√© ni√Īos de la familia presentan riesgo de c√°ncer y pueden beneficiarse de las pruebas de detecci√≥n precoz, as√≠ como aquellos que no han heredado la mutaci√≥n y no presentan un incremento del riesgo”.
agosto 7/2014 (Diario Médico)

Sandra Hanks,Elizabeth R. Perdeaux,Sheila Seal,Elise Ruark,Shazia S. Mahamdallie,Anne Murray.Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour open.Nature Communications 5.7 Ago 2014

Terapia con células madre muestra resultados prometedores para tratar el ictus 20 Aug 2014


Strict Standards: Non-static method SimplePie_Misc::get_element() should not be called statically, assuming $this from incompatible context in /home/cubaheal/public_html/classes/simplepie/simplepie.inc on line 13264

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Los resultados obtenidos muestran que el tratamiento es seguro y eficaz. Las posibilidades de recuperación podrían aumentar con una aplicación temprana.

c√©lulas madresSeg√ļn un estudio publicado en Stem Cells Translational Medicine (doi:10.5966/sctm.2013-0178), una terapia para el ictus utilizando c√©lulas madre extra√≠das de la m√©dula √≥sea de pacientes ha mostrado resultados prometedores en el primer ensayo en humanos.

Cinco pacientes recibieron el tratamiento en un estudio piloto realizado por científicos del Imperial College Healthcare NHS Trust y del Imperial College London (Reino Unido). La terapia utiliza un tipo de célula llamada CD34+, un conjunto de células madre de la médula espinal que produce células sanguíneas y células que recubren los vasos sanguíneos.

Los pacientes fueron tratados a los siete días de un ictus grave, a diferencia de otros ensayos con células madre, muchos de los cuales han tratado a los pacientes tras seis meses o más. Los investigadores creen que un tratamiento temprano puede incrementar las posibilidades de una mejor recuperación.

Se extrajo una muestra de médula espinal de cada paciente. Las células CD34+ fueron aisladas de la muestra y luego infundidas en una arteria que suministra sangre al cerebro. Todos los pacientes mostraron mejoras en las pruebas clínicas durante el periodo de seguimiento de seis meses. Cuatro de los cinco pacientes padecían un tipo de ictus muy grave. Seis meses después, estos cuatro pacientes seguían vivos y tres eran independientes.

“Este estudio muestra que el tratamiento parece ser seguro y muestra que es posible tratar pronto a los pacientes. Las mejoras observadas son esperanzadoras, aunque todav√≠a es demasiado pronto para trazar unas conclusiones definitivas sobre la efectividad de la terapia. Necesitamos hacer m√°s pruebas para calcular la mejor dosis y la duraci√≥n del tratamiento antes de comenzar con ensayos m√°s amplios”, explica Soma Banerjee, del Imperial College Healthcare NHS Trust.

“√Čste es el primer ensayo que a√≠sla las c√©lulas humanas de la m√©dula √≥sea y las inyecta directamente en la regi√≥n cerebral da√Īada utilizando t√©cnicas m√≠nimamente invasivas”, se√Īala Paul Bentley, del Imperial College London.
agosto 8 /2014 (Diario Médico)

Soma Banerjee,Paul Bentley,Mohammad Hamady,Stephen Marley,John Davis,Abdul Shlebak¬ī.Intra-Arterial Immunoselected CD34+ Stem Cells for Acute Ischemic Stroke.Stem Cells Trans Med .Ago¬† 8, 2014

 
 
 
Clínica Central Cira García
IPK (Instituto de Medicina Tropical)
IPK (Instituto de Medicina Tropical)
INOR
Instituto Nacional de Oncológica y Radiobiologia
Ciren
CIREN(Centro Internacional de Restauración Neurológica).
Centro de Salud La Pradera
Centro Internacional de Salud La Pradera
 
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