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Vacuna contra el ébola probada con éxito en monos 2 Sep 2014


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La empresa canadiense ImmunoVaccine desarrolló una vacuna experimental contra el ébola que ha sido probada con éxito en monos expuestos al virus.

OMS 1Cuatro animales infectados recibieron el tratamiento y varios d√≠as despu√©s sobrevivieron a la enfermedad, inform√≥ la compa√Ī√≠a con sede en Nueva Escocia.

También indicó que otros dos monos infectados al mismo tiempo, pero que no fueron inmunizados fallecieron una semana después. Todas las pruebas se realizaron en la sede de los Institutos Nacionales de Estados Unidos, con sede en Maryland.

Hace ya m√°s de seis meses que comenz√≥ un brote de √©bola en Guinea Conakry, el cual se extendi√≥ r√°pidamente hacia otras naciones de √Āfrica occidental. Desde entonces, m√°s de dos mil 473 personas enfermaron, mil 450 de las cuales fallecieron por esta causa.

POr otra parte, la Organizaci√≥n Mundial de la Salud (OMS), se√Īal√≥ que unos 130 trabajadores sanitarios murieron. Al menos 225 han sido afectados, y por primera vez, un experto del organismo de Naciones Unidas contrajo la enfermedad.

Se trata de un epidemiólogo senegalés enviado por la OMS a trabajar a Sierra Leona, indicó la agencia en un comunicado.

Desde que empezó el actual brote de ébola, el pasado marzo, varios médicos, enfermeras y personas que cumplen otras funciones de atención a pacientes de ébola se contagiaron con el peligroso virus, algunos murieron.

Seg√ļn la OMS ello se debe a la fragilidad de los sistemas sanitarios de los pa√≠ses afectados, la falta de equipamiento b√°sico, incluidos aquellos para la protecci√≥n personal, y desconocimiento de la manera c√≥mo tratar a los enfermos, entre otras causas.

Guinea Cronaky, Liberia, Nigeria y Sierra Leona son las naciones donde se han reportado casos.

El primer británico que contrajo el virus del ébola, y que fue infectado en Sierra Leona, fue trasladado a su país, donde será tratado.

El paciente, que seg√ļn las autoridades “no est√° gravemente enfermo”, es un m√©dico que trabajaba para una asociaci√≥n humanitaria en Sierra Leona. Su nombre no ha sido comunicado.

Tambi√©n se report√≥ la presencia del √©bola en una provincia de la Rep√ļblica del Congo.
agosto 26/2014 (PL)

Tomado del bolet√≠n de selecci√≥n tem√°tica de Prensa Latina: Copyright 2013 ‚ÄúAgencia Informativa Latinoamericana Prensa Latina S.A.‚ÄĚ

Una nueva vacuna podría ser eficaz contra la tuberculosis y la lepra 2 Sep 2014


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Investigadores de la Universidad de California en Los √Āngeles (Estados Unidos) han descubierto una nueva vacuna que podr√≠a ser eficaz en el tratamiento de la tuberculosis y la lepra.

nueva vacunaEl estudio, publicado en Infection and Immunity (doi: 10.1128/IAI.01499-13.), indica que rBCG30, una variante recombinante de BCG (Bacille Calmette-Guerin en sus siglas en inglés) que se sobreexpresa en kDa 30, una proteína muy abundante de la bacteria de la tuberculosis conocida como Antígeno 85b, podría proteger de manera más eficaz que BCG contra la tuberculosis, solo en modelos animales, y la lepra en humanos. Además, los investigadores descubrieron que impulsando rBCG30 con la proteína Antígeno 85b, que también está presente en el bacilo de la lepra, se protegía significativamente al paciente contra la lepra.

Diferente efectividad en ratones y humanos
Para la investigación, Marcus A. Horwitz, profesor de medicina y microbiología, y sus colaboradores inmunizaron a un grupo de ratones con rBCG30 y a otro con la antigua vacuna BCG, siendo al mismo tiempo inmunizados también con una vacuna de refuerzo (r30) que contiene a la bacteria de la tuberculosis 30kDa de la proteína Antígeno 85B en adyuvante, que resulta la formulación química que aumenta la respuesta inmunológica. El grupo que había sido inmunizado con rBCG30 y con la vacuna de refuerzo no presentaron la bacteria de la lepra en sus almohadillas, a diferentes del grupo al que se le inmunizó con la otra vacuna.

En otro experimento, la respuesta inmunológica de los ratones se medió después de la inyección, descubriendo que los ratones inmunizados con rBCG30 y potenciado con r30 presentaban una mejora significativa en la respuesta inmunológica a la versión bacteriana de la lepra de la proteína Antígeno 85b en comparación con los ratone inmunizaos con otras vacunas o combinaciones.

En la Fase I del ensayo con rBCG30 se comprob√≥ que esta proteg√≠a significativamente al paciente y resultaba m√°s eficaz que la tradicional BCG. A pesar de estos resultados, los autores del estudio advierten de que a√ļn es necesario realizar m√°s investigaciones para estimar la efectividad de la vacuna rBCG30 en humanos.
agosto 20/2014 (Diario Médico)

Gillis TP, Tullius MV, Horwitz MA.rBCG30-Induced Immunity and Cross-Protection against Mycobacterium leprae Challenge Are Enhanced by Boosting with the Mycobacterium tuberculosis 30-Kilodalton Antigen 85B.Infect Immun. 2014 Sep;82(9):3900-9  2014 Jul 7.

El aumento de la oximetr√≠a en ni√Īos con bronquitis disminuir√≠a las hospitalizaciones 2 Sep 2014


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Los ni√Īos que acuden a urgencias por una bronquitis de leve a moderada y cuya medici√≥n muestra una saturaci√≥n de ox√≠geno artificial m√°s elevada son menos propensos a ser hospitalizados o a recibir asistencia hospitalaria durante m√°s de 6 horas.

oximetr√≠aUn estudio realizado por Suzanne Schuh del Hospital para Ni√Īos Enfermos de Toronto (Canad√°) y su equipo indica que de todos los ni√Īos que acuden de emergencia al departamento de pediatr√≠a por una bronquitis de leve a moderada, aquellos cuya medici√≥n muestra una saturaci√≥n de ox√≠geno artificial m√°s elevada son menos propensos a ser hospitalizados o a recibir asistencia hospitalaria durante m√°s de 6 horas que los que registran mediciones alteradas.

B√ļsqueda de procedimientos eficaces
El objetivo de este ensayo consistía en determinar si el aumento de la oximetría en tres puntos porcentuales por encima de los valores verdaderos disminuiría la probabilidad de hospitalización dentro de las 72 horas o la atención hospitalaria durante más de 6 horas.

Para la investigaci√≥n, publicada en JAMA (doi:10.1001/jama.2014.8637), se utiliz√≥ una muestra de 213 ni√Īos sanos de entre cuatro semanas y 12 meses de edad, procedentes del tercer nivel del Departamento de Emergencias Pedi√°trica en Toronto, que padec√≠an una bronquiolitis de leve a moderada. Esta muestra se dividi√≥ en dos subgrupos, el primero con oximetr√≠a verdadera y el segundo con oximetr√≠a alterada.

Los resultados mostraron que el 41% de los ni√Īos con oximetr√≠a verdadera fueron hospitalizados en 72 horas, mientras que de los que ten√≠a una oximetr√≠a alterada solo fueron hospitalizados en este periodo de tiempo el 25 %. Los investigadores tambi√©n detectaron que 23 de las 108 (21,3 %) visitas m√©dicas posteriores no programadas fueron por bronquiolitis en el grupo con oximetr√≠a verdadera, mientras que en el grupo con oximetr√≠a alterada fueron 15 de 105 (14,3 %).

Los autores del estudio concluyeron por tanto que si se aumenta artificialmente la manifestaci√≥n de la oximetr√≠a en pacientes de urgencias que tengan de una leve a moderada bronquiolitis por una peque√Īa cantidad fisiol√≥gica, reducir√≠a significativamente las hospitalizaciones dentro de las 72 horas o la atenci√≥n hospitalaria activa durante m√°s de 6 horas.
agosto 20/2014 (Diario Médico)

Suzanne Schuh, Stephen Freedman,  Allan Coates, Upton Allen, Patricia C. Parkin, Derek Stephens.Effect of Oximetry on Hospitalization in BronchiolitisA Randomized Clinical Trial.JAMA. 2014;312(7):712-718.Ago 20, 2014

Un estudio muestra nuevas perspectivas sobre el funcionamiento del reloj biológico 2 Sep 2014


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Determinar c√≥mo act√ļan los relojes circadianos es crucial para entender muchas de las enfermedades humanas como los trastornos del sue√Īo o la depresi√≥n.

relojSeg√ļn un estudio publicado en Nature, investigadores de la Universidad de Texas (EEUU) han encontrado una nueva v√≠a por la que los relojes biol√≥gicos internos son regulados por un tipo de mol√©cula conocida como RNA no codificante.

El equipo de investigadores fue capaz de aprender más sobre los ritmos circadianos estudiando sistemas modelo del moho del pan, Neurospora crassa. Los investigadores encontraron que la expresión de un gen reloj llamado frecuencia (frq, en inglés) es controlada por un ARN no codificante llamado qrf. Al contrario que las moléculas ARN normales, qrf no codifica una proteína, sino que controla la producción de la proteína frq.

Modo de acción
El ARN qrf se produce en respuesta a la luz y puede interferir con la producción de la proteína frq. De este modo, qrf puede reiniciar el reloj circadiano de un modo dependiente de la luz. Esta regulación funciona de ambos modos: frq puede bloquear la producción de qrf. Esta inhibición mutua garantiza que las moléculas ARN frq y qrf estén presentes en fases opuestas del reloj y permite que el ARN oscile enérgicamente. Sin qrf, los ritmos circadianos normales no se sostienen, lo cual indica que el ARN no codificante es necesario para las funciones del reloj.

“Anticipamos un modo de acci√≥n similar que podr√≠a funcionar en otros organismos porque hemos encontrado ARNs parecidos en genes reloj de roedores. Adem√°s, los ARN podr√≠an funcionar tambi√©n en otros procesos biol√≥gicos por su presencia en los genomas”, ha explicado Yi Liu, de la Universidad de Texas.

“Este estudio muestra la ubicuidad del reloj circadiano en las especies, incluyendo los humanos, y su papel en la regulaci√≥n metab√≥lica de las c√©lulas, los √≥rganos y los organismos”, ha afirmado Michael Sesma, del National Institute of General Medical Sciences (EEUU). “Los nuevos resultados obtenidos se extienden m√°s all√° de entender la funci√≥n del ARN antisentido en el ritmo diario celular; proporcionan un ejemplo del motivo por el que la transcripci√≥n del ARN antisentido regula otros procesos moleculares y fisiol√≥gicos en c√©lulas y √≥rganos”.
agosto 19/2014 (Diario Médico)

Zhihong Xue, Qiaohong Ye, Simon R. Anson, Jichen Yang, Guanghua Xiao.Transcriptional interference by antisense RNA is required for circadian clock function.Nature .17 Ago 2014

Una dieta rica en ácidos grasos omega 3 podría prevenir la esclerosis lateral amiotrófica 2 Sep 2014


Strict Standards: Non-static method SimplePie_Misc::get_element() should not be called statically, assuming $this from incompatible context in /home/cubaheal/public_html/classes/simplepie/simplepie.inc on line 13264

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Una dieta rica en ácidos grasos omega 3 podría ayudar a reducir el riesgo de esclerosis lateral amiotrófica (ELA). Estos ácidos grasos (habituales en ciertos pescados) son conocidos porque reducen la inflamación y el estrés oxidativo en las células.

Omega 3Los investigadores realizaron un análisis observacional longitudinal basado en 1 002 082 participantes (479 114 mujeres y 522 968 hombres) de cinco cohortes distintas. Finalmente documentaron 995 casos de ELA, que se distribuyeron en quintiles. Una mayor ingesta de ácidos grasos omega 3 se asoció con una reducción del riesgo de ELA. Las personas que quedaron encuadradas dentro del 20 % de quienes ingirieron más ácidos grasos omega 3 redujeron sus probabilidades de contraer ELA en un tercio, en comparación con los que quedaron incluidos dentro del quintil correspondiente a quienes tomaron menos ácidos grasos omega 3.

Una mayor ingesta de ácido a-linolénico, un tipo de ácido graso presente en los aceites vegetales y en los frutos secos, también se asoció con un riesgo de ELA menor.

Sin embargo, el estudio sólo observó el riesgo de contraer ELA. No se sabe si un elevado nivel alto de ingesta de ácidos grasos omega 3 podría ayudar a las personas que ya sufren la enfermedad.
agosto 21/2014 (Neurologia.com)

Fitzgerald KC, O’Reilly EJ, Falcone GJ, McCullough ML, Park Y, Kolonel LN.Dietary ?-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis.JAMA Neurol. Jul 14, 2014. doi:10.1001/jamaneurol.2014.1214

Dos vacunas ayudan a reducir la cantidad de bacterias que provocan meningitis 2 Sep 2014


Strict Standards: Non-static method SimplePie_Misc::get_element() should not be called statically, assuming $this from incompatible context in /home/cubaheal/public_html/classes/simplepie/simplepie.inc on line 13264

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Dos nuevas vacunas pueden reducir la propagaci√≥n de la meningitis al reducir la cantidad de bacterias que provocan la meningitis que portan las personas, seg√ļn un nuevo estudio.

meningitisLos investigadores realizaron pruebas con dos vacunas (MenACWY-CRM y 4CMenB) en voluntarios de 18 a 24 a√Īos de edad. MenACWY-CRM disminuy√≥ las poblaciones de bacterias que provocan la meningitis en la nariz y en la garganta en un 39 %, y 4CMenB redujo dichas poblaciones en un 20 y un 30 %.

Los hallazgos, publicados en la revista The Lancet, podr√≠an cambiar el modo en que se hacen las nuevas vacunas en el futuro, seg√ļn el investigador principal, el Dr. Robert Read, profesor de enfermedades infecciosas en la Universidad de Southampton del Reino Unido.

“La pr√°ctica est√°ndar es vacunar con el objetivo de inducir unos niveles altos de anticuerpos en la sangre para que protejan de la enfermedad, pero sabemos que estos anticuerpos pueden desaparecer despu√©s de unos pocos meses”, dijo Read en un comunicado de prensa de la universidad.

“Este estudio nos dice que las vacunas tambi√©n tienen un efecto en la carga que hay en la garganta y explica por qu√© pueden ser tan efectivas en la poblaci√≥n”, a√Īadi√≥.

La meningitis es una infecci√≥n de las membranas que recubren el cerebro y la espina dorsal. Las bacterias que provocan la meningitis son comunes y est√°n presentes en la nariz y la garganta de forma inocua en aproximadamente el 10 por ciento de las personas. Las bacterias pueden pasar de una persona a otra a trav√©s del contacto cercano. Cualquier persona puede contraer meningitis, pero los beb√©s y los ni√Īos peque√Īos son los que tienen un riesgo mayor, seg√ļn la informaci√≥n de respaldo en el comunicado de prensa.

“Se trata de un trabajo significativo a la hora de ayudar a que cada vez m√°s personas est√©n protegidas contra la meningitis. Hemos mostrado que las vacunas modifican el modo en que las bacterias se trasportan, de manera que cuando los anticuerpos ya no est√°n presentes en la sangre todav√≠a se puede prevenir que est√©n presentes en la garganta, y tambi√©n la transmisi√≥n externa de la infecci√≥n a otras personas”, explic√≥ Read.

“Esto podr√≠a proporcionar un grado de protecci√≥n grupal contra la meningitis si se implementara una campa√Īa en las personas en las que se transmite mucho, como, por ejemplo, en los adolescentes y en los adultos j√≥venes”, se√Īal√≥
agosto 20/2014 (MedlinePlus)
Robert C Read , David Baxter , David R Chadwick, Saul N Faust , Adam Finn , Stephen B Gordon. Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial.The Lancet, 19 Ago 2014

 
 
 
Clínica Central Cira García
IPK (Instituto de Medicina Tropical)
IPK (Instituto de Medicina Tropical)
INOR
Instituto Nacional de Oncológica y Radiobiologia
Ciren
CIREN(Centro Internacional de Restauración Neurológica).
Centro de Salud La Pradera
Centro Internacional de Salud La Pradera
 
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